2-(Trimethylsilyl)ethanol is widely used in organic synthesis for the introduction of the 2-(trimethylsilyl)ethyl (TMSE) protecting group, particularly for phosphate and carboxylic acid functionalities. The TMSE group provides stable protection that can be selectively removed under mild fluoride conditions, making it essential in the synthesis of pharmaceuticals, nucleosides, and complex natural products. Additionally, it serves as a precursor in the preparation of silicon-containing polymers and materials, contributing to coatings, adhesives, and surface modifiers. Its applications extend to surface chemistry, where it modifies surfaces for improved hydrophobicity or compatibility with other materials.