Used primarily as a silylating agent in organic synthesis, enabling protection of hydroxyl and carboxyl groups during multi-step reactions. Its reactivity allows for selective functional group manipulation, especially in the synthesis of complex molecules like pharmaceuticals and natural products. It also serves as a derivatizing agent in analytical chemistry, improving volatility and thermal stability of polar compounds for gas chromatography and mass spectrometry analysis. Additionally, it finds use in the preparation of silane-based coupling agents for surface modification of materials such as glass, metals, and polymers, enhancing adhesion in coatings and composites.