ME0328 is primarily utilized in biochemical research as a selective inhibitor of SIRT2, a member of the sirtuin family of NAD+-dependent deacetylases. Its application is significant in studying the role of SIRT2 in various cellular processes, including cell cycle regulation, neurodegeneration, and cancer. Researchers employ ME0328 to investigate the potential therapeutic effects of SIRT2 inhibition in diseases such as Parkinson's and Huntington's, where SIRT2 activity is implicated in disease progression. Additionally, it is used in cancer research to explore its impact on tumor growth and metastasis, providing insights into novel treatment strategies.