Spiro[indene-1,4'-piperidine] hydrochloride is primarily utilized in the field of medicinal chemistry as a key intermediate in the synthesis of various pharmaceutical compounds. It is particularly significant in the development of central nervous system (CNS) drugs, where it serves as a building block for creating molecules that target neurological disorders such as depression, anxiety, and schizophrenia. The spirocyclic structure of the compound provides a unique three-dimensional framework that enhances binding affinity and selectivity to specific receptors in the brain. Additionally, its hydrochloride salt form improves solubility and stability, making it more suitable for formulation into drug products. Researchers also explore its potential in designing novel therapeutics for pain management and neurodegenerative diseases due to its ability to modulate neurotransmitter systems effectively.