Dehydroepiandrosterone sulfate is widely used in medical diagnostics as a biomarker to assess adrenal gland function. It helps in evaluating conditions like adrenal hyperplasia, adrenal tumors, and certain endocrine disorders. In clinical research, it is studied for its potential role in aging, immune function, and metabolic health. Additionally, it has been explored in the context of hormone replacement therapy and its effects on mood, cognition, and overall vitality. Some studies also investigate its role in managing symptoms of menopause and andropause, though its therapeutic applications remain under research.