Used primarily in hormone replacement therapy (HRT) to alleviate symptoms of menopause such as hot flashes, vaginal dryness, and osteoporosis. It is also applied in veterinary medicine to manage hormonal imbalances in animals. In research, it serves as a tool to study estrogen receptor activity and its effects on various tissues. Additionally, it is utilized in the development of estrogen-based pharmaceuticals and treatments for conditions related to estrogen deficiency.