Used as a fluorinating reagent in organic synthesis, particularly in the introduction of the pentafluorosulfur (SF5) group into aromatic compounds. The SF5 group is highly electronegative and lipophilic, making this compound valuable in the development of pharmaceuticals, agrochemicals, and materials with enhanced metabolic stability and bioavailability. It serves as a building block for creating high-performance liquid crystals and energetic materials due to the thermal and chemical stability imparted by the SF5 moiety. Its application in medicinal chemistry includes the design of novel drug candidates where improved resistance to oxidative degradation is required.