2-D08 is primarily used in research settings as a selective inhibitor of SUMOylation, a post-translational modification process that regulates protein function. It is particularly valuable in studying the role of SUMOylation in cellular processes such as protein localization, stability, and interactions. Researchers utilize 2-D08 to investigate its effects on signaling pathways, DNA repair mechanisms, and stress responses, providing insights into diseases like cancer and neurodegenerative disorders. Its application helps in understanding the therapeutic potential of targeting SUMOylation in various pathological conditions.