Genz-644282 is a potent and selective inhibitor of poly(ADP-ribose) polymerase (PARP-1 and PARP-2) enzymes, primarily utilized in the field of medical research, particularly in the study of cancer therapies. These enzymes play a crucial role in DNA repair mechanisms that support the survival and proliferation of cancer cells. By targeting PARP, Genz-644282 helps in disrupting these cellular processes, leading to synthetic lethality in tumors with DNA repair deficiencies, such as BRCA-mutated cancers. This makes it a valuable compound in the development of new anticancer drugs, offering potential for more effective treatments with fewer side effects compared to traditional chemotherapy. Researchers are also exploring its use in combination with other therapeutic agents to enhance its efficacy and overcome drug resistance in various types of cancers.