tert-Butyl (4-bromo-5-formylthiazol-2-yl)carbamate
97%
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description Product Description
Used as an intermediate in the synthesis of biologically active compounds, particularly in pharmaceuticals targeting kinase inhibitors and antimicrobial agents. Its aldehyde group at the 5-position allows for further functionalization via reactions such as reductive amination or Wittig transformations, enabling the construction of complex heterocyclic systems. The 4-bromo substituent facilitates derivatization through cross-coupling reactions, such as Suzuki or Heck couplings, for introducing aryl or alkenyl groups. The tert-butyl carbamate (Boc) group provides protection for the amine during multi-step syntheses, ensuring selective reactivity. Commonly employed in medicinal chemistry for developing thiazole-based drug candidates due to the scaffold’s metabolic stability and favorable binding properties.
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