Used as a catalyst precursor in organic synthesis, particularly in thiamine-dependent enzymatic reactions and biomimetic transformations. It plays a key role in umpolung (polarity reversal) reactions, enabling unconventional bond formations such as benzoin condensations and Stetter reactions. Also applied in studies of enzyme mechanisms related to thiamine pyrophosphate coenzymes. Its ionic structure enhances solubility in polar solvents, making it suitable for homogeneous catalysis in aqueous and mixed solvent systems.