Used as a protecting group reagent in organic synthesis, particularly for masking thiol groups due to its stability under various reaction conditions. Its bulky triisopropylsilyl group provides steric protection, making it effective in multi-step syntheses where selective deprotection is required. Commonly employed in peptide and nucleotide chemistry to prevent unwanted side reactions. Also utilized in materials science for surface modification of nanoparticles and semiconductors, where the thiol moiety binds to metal surfaces while the silyl group imparts hydrophobicity and stability.