TR antagonist 1 is primarily used in research and pharmaceutical development to study and modulate thyroid hormone receptor (TR) activity. It is employed to investigate the role of thyroid hormone signaling in various physiological processes, such as metabolism, growth, and development. By blocking TR activity, it helps researchers understand the implications of reduced thyroid hormone signaling in diseases like hyperthyroidism, thyroid cancer, and metabolic disorders. Additionally, it serves as a potential lead compound for developing therapeutic agents targeting TR-related conditions. Its application is crucial in preclinical studies to evaluate efficacy and safety in modulating thyroid hormone pathways.