Cetirizine dihydrochloride

  • Product Code: 126113

recently found to have good efficacy in reducing hair loss

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Test Name Specification
Description White to almost white powder. Freely soluble in water; practically insoluble in acetone and in methylene chloride.
Identification - IR The infrared spectrum should be concordant with the reference spectrum.
Identification - Chloride Should be positive reaction
Deschlorocetirizine Max 0.1%
Cetirizine ethanol Max 0.1%
CBHP Max 0.1%
2-Chlorocetirizine Max 0.1%
Cetirizine methyl ester Max 0.1%
3-Chlorocetirizine Max 0.1%
Cetirizine acetic acid Max 0.1%
Cetirizine N-oxide Max 0.1%
4-CBH Max 0.1%
4-Chlorobenzophenone Max 0.1%
Cetirizine dimer Max 0.1%
Any individual unspecified impurity Max 0.10%
Total impurities Max 0.3%
pH 1.2 - 1.8
Loss on Drying Max 0.5%
Sulfated ash Max 0.2%
Assay 98.0% - 102.0% on the dried basis

this item Can be sold only to hospitals, clinics, drug factories, pharmacists, doctors for use in research only. The purchaser must submit the following documents: Natural Person: Medical certificate or pharmacist Juristic Person: Documents received around the drug manufacturing site or a document certifying the hospital (clinic/hospital)

 

Cetirizine dihydrochloride recently found to have good efficacy in reducing hair loss

Pharmaceutical sciences branch, Islamic Azad University, Tehran, Iran;2Center for Research & Training in Skin Diseases & Leprosy, Tehran University ofMedical Sciences, Tehran, Iran.; 3Department of Pharmaceutics, Faculty of Pharmacy,Tehran University of Medical Sciences, Tehran, Iran;4Legacy Healthcare SA, Epalinges, Switzerland

  • Study Purpose: Cetirizine, an antihistamine, is hypothesized to benefit hair growth by inhibiting prostaglandin D2 (which promotes hair loss) and stimulating prostaglandin E2 (which promotes hair growth). The study aimed to evaluate the effectiveness and safety of cetirizine for AGA compared to minoxidil, a well-established hair growth treatment.

  • Methodology:

    • Participants: 40 men with AGA were divided into two groups, each using either cetirizine 1% or minoxidil 5% for 16 weeks, followed by 8 weeks of placebo.
    • Assessment: Hair density, diameter, and phases (anagen and telogen) were measured at the start, after 16 weeks, and again after the placebo period.
  • Results:

    • Hair Density: Both cetirizine and minoxidil significantly increased hair density, though minoxidil showed a more substantial effect.
    • Hair Phases: An increase in hair in the anagen phase (growth phase) was observed in both groups, though it slightly decreased after the placebo.
    • Patient and Physician Feedback: Patients and physicians noted improvements in hair density with both treatments, with minoxidil yielding higher satisfaction scores initially. However, cetirizine was found to maintain some effects even after stopping, indicating potential for longer-term use.
    • Safety: Cetirizine had fewer side effects compared to minoxidil, which caused mild pruritus and scaling in some cases.
  • Conclusion: Cetirizine 1% is effective for AGA treatment and may offer a safer alternative for those who experience side effects from minoxidil. Further research with larger samples and varied concentrations could provide more insights.

 

Use: use in medicine only Not allowed to use in cosmetics

Product characteristics: White powder, soluble in water.

Storage: For long term storage keep in refrigerator Do not expose to sunlight, heat, seal the lid tightly, shelf life at least 2 years.

 

Chemical Name : Cetirizine dihydrochloride




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Cetirizine dihydrochloride

recently found to have good efficacy in reducing hair loss

this item Can be sold only to hospitals, clinics, drug factories, pharmacists, doctors for use in research only. The purchaser must submit the following documents: Natural Person: Medical certificate or pharmacist Juristic Person: Documents received around the drug manufacturing site or a document certifying the hospital (clinic/hospital)

 

Cetirizine dihydrochloride recently found to have good efficacy in reducing hair loss

Pharmaceutical sciences branch, Islamic Azad University, Tehran, Iran;2Center for Research & Training in Skin Diseases & Leprosy, Tehran University ofMedical Sciences, Tehran, Iran.; 3Department of Pharmaceutics, Faculty of Pharmacy,Tehran University of Medical Sciences, Tehran, Iran;4Legacy Healthcare SA, Epalinges, Switzerland

  • Study Purpose: Cetirizine, an antihistamine, is hypothesized to benefit hair growth by inhibiting prostaglandin D2 (which promotes hair loss) and stimulating prostaglandin E2 (which promotes hair growth). The study aimed to evaluate the effectiveness and safety of cetirizine for AGA compared to minoxidil, a well-established hair growth treatment.

  • Methodology:

    • Participants: 40 men with AGA were divided into two groups, each using either cetirizine 1% or minoxidil 5% for 16 weeks, followed by 8 weeks of placebo.
    • Assessment: Hair density, diameter, and phases (anagen and telogen) were measured at the start, after 16 weeks, and again after the placebo period.
  • Results:

    • Hair Density: Both cetirizine and minoxidil significantly increased hair density, though minoxidil showed a more substantial effect.
    • Hair Phases: An increase in hair in the anagen phase (growth phase) was observed in both groups, though it slightly decreased after the placebo.
    • Patient and Physician Feedback: Patients and physicians noted improvements in hair density with both treatments, with minoxidil yielding higher satisfaction scores initially. However, cetirizine was found to maintain some effects even after stopping, indicating potential for longer-term use.
    • Safety: Cetirizine had fewer side effects compared to minoxidil, which caused mild pruritus and scaling in some cases.
  • Conclusion: Cetirizine 1% is effective for AGA treatment and may offer a safer alternative for those who experience side effects from minoxidil. Further research with larger samples and varied concentrations could provide more insights.

 

Use: use in medicine only Not allowed to use in cosmetics

Product characteristics: White powder, soluble in water.

Storage: For long term storage keep in refrigerator Do not expose to sunlight, heat, seal the lid tightly, shelf life at least 2 years.

 

Chemical Name : Cetirizine dihydrochloride

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