(R)-TCO-OH is widely utilized in bioorthogonal chemistry due to its rapid and selective reactivity with tetrazines, making it a valuable tool for labeling and imaging in biological systems. It is commonly employed in click chemistry reactions to modify biomolecules such as proteins, nucleic acids, and lipids without interfering with native biological processes. This compound is particularly useful in live-cell imaging, where it enables real-time tracking of cellular components and processes. Additionally, it plays a significant role in the development of targeted drug delivery systems, where it facilitates the conjugation of therapeutic agents to specific biomolecules or nanoparticles. Its stability and efficiency in complex biological environments make it a preferred choice for advanced research in chemical biology and medical diagnostics.