TCO-amine is widely utilized in bioorthogonal chemistry due to its ability to participate in rapid and selective reactions with tetrazines. This property makes it highly valuable in the field of bioconjugation, where it is used to label biomolecules such as proteins, antibodies, and nucleic acids for imaging, diagnostics, and therapeutic applications. Its fast reaction kinetics and biocompatibility enable efficient tagging and tracking of biological targets in live cells and organisms. Additionally, TCO-amine is employed in the development of targeted drug delivery systems, where it facilitates the precise attachment of therapeutic agents to specific cells or tissues, enhancing treatment efficacy while minimizing off-target effects. Its versatility also extends to materials science, where it is used to modify surfaces and polymers for functionalization and advanced material design.