This compound is widely used in bioconjugation and click chemistry applications due to its reactive trans-cyclooctene (TCO) group, which enables rapid and efficient reactions with tetrazine derivatives. It is particularly valuable in the development of targeted drug delivery systems, where it facilitates the attachment of therapeutic agents to biomolecules or nanoparticles. Additionally, it is employed in the labeling and imaging of biomolecules, such as proteins and antibodies, for research and diagnostic purposes. The PEG spacer enhances solubility and reduces steric hindrance, improving the efficiency of conjugation processes. Its applications also extend to the field of materials science, where it is used to modify surfaces or create functionalized polymers for advanced material design.