D-Lin-MC3-DMA
≥99%
Reagent
Code: #61733
Alias
(Dilinoleyl)methyl 4-(N,N-dimethylamino)butanoate; (6Z,9Z,28Z,31Z)-heptatriacont-6,9,28,31-tetraene-19-yl 4- (dimethylamino)butanoate
CAS Number
1224606-06-7
Properties
Insoluble in water, easily soluble in DMSO, methanol, ethanol. the
science Other reagents with same CAS 1224606-06-7
blur_circular Chemical Specifications
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Molecular Information
Weight
642.09 g/mol
Formula
C₄₃H₇₉NO₂
thermostat
Physical Properties
Boiling Point
670.2±43.0 °C(Predicted)
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Storage & Handling
Density
0.886±0.06 g/cm3(Predicted)
Storage
-20℃
description Product Description
D-Lin-MC3-DMA is an ionizable cationic lipid widely used in the development of lipid nanoparticles (LNPs) for nucleic acid delivery systems, particularly siRNA and mRNA therapeutics. It is the key lipid component in Onpattro (patisiran), the first FDA-approved LNP-siRNA drug for hereditary transthyretin-mediated amyloidosis. This compound enhances the stability, cellular uptake, and endosomal escape of nucleic acids while minimizing toxicity. It is also extensively researched for mRNA vaccines, cancer immunotherapies, and gene editing applications, advancing precision medicine through efficient and safe delivery of genetic material.
format_list_bulleted Product Specification
| Test Parameter | Specification |
|---|---|
| Appearance | Oily liquid |
| Purity | 98.5-100 |
| Infrared Spectrum | Conforms to Structure |
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