SKF-96365 is primarily used in research settings as a potent inhibitor of store-operated calcium entry (SOCE) and transient receptor potential (TRP) channels. It is widely utilized in studies focusing on calcium signaling pathways, particularly in understanding the role of calcium influx in cellular processes. Researchers employ it to investigate its effects on immune cell activation, endothelial cell function, and neuronal signaling. Additionally, SKF-96365 has been explored in experimental models of inflammation, cancer, and cardiovascular diseases to assess its potential therapeutic applications. Its ability to modulate calcium channels makes it a valuable tool for studying various physiological and pathological conditions.