AMG-517 is primarily used in scientific research to study pain pathways, particularly those involving heat and inflammation. It acts as a potent antagonist of the TRPV1 receptor, which is activated by high temperatures, capsaicin, and acidic conditions. By blocking this receptor, AMG-517 helps researchers understand the role of TRPV1 in chronic pain conditions such as neuropathic pain and inflammatory pain. It has been investigated for its potential to reduce pain without affecting normal body temperature regulation, although development for clinical use was discontinued due to side effects like elevated body temperature. Despite this, it remains a valuable tool compound in preclinical studies aimed at developing new analgesic drugs.