AMG PERK 44 is a selective inhibitor of the PERK enzyme (PKR-like ER kinase), primarily utilized in research and development within the pharmaceutical and biomedical fields. It is studied for its role in modulating the endoplasmic reticulum (ER) stress response, particularly those related to cellular signaling and metabolic processes. Researchers investigate its effects on protein kinase activity, interactions, and enzyme inhibition, aiming to uncover therapeutic applications for diseases such as cancer, neurological disorders, and diabetes where these pathways are dysregulated. Additionally, it may be used in preclinical studies to evaluate its efficacy and safety as a potential drug candidate, contributing to advancements in targeted therapies related to ER stress. Its application is largely confined to laboratory settings, where it aids in understanding complex biochemical mechanisms.