5-Fluoro-2-(trifluoromethyl)benzoyl Chloride
97%
Reagent
Code: #187501
CAS Number
216144-70-6
science Other reagents with same CAS 216144-70-6
blur_circular Chemical Specifications
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Molecular Information
Weight
226.55 g/mol
Formula
C₈H₃ClF₄O
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Registry Numbers
MDL Number
MFCD00083534
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Physical Properties
Boiling Point
169°C (Lit.)
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Storage & Handling
Storage
2-8°C, sealed, dry
description Product Description
Used primarily as an intermediate in the synthesis of pharmaceuticals and agrochemicals, this compound plays a key role in introducing fluorinated benzoyl groups into larger molecules. Its high reactivity makes it valuable in the preparation of herbicides and fungicides, where the fluorine atoms enhance biological activity and stability. It is also employed in the development of active pharmaceutical ingredients, particularly in drugs targeting central nervous system disorders and inflammation. Due to the presence of both fluorine and trifluoromethyl groups, it contributes to improved metabolic resistance and membrane permeability in drug candidates. Commonly used in carbonyl coupling reactions, it reacts with amines and alcohols to form amides and esters, respectively, which are essential structural motifs in many bioactive compounds.