Fmoc-L-Arg(Me,Me)-OH(asymmetrical)
≥97%
Reagent
Code: #187792
Alias
N5-[(dimethylamino)iminomethyl]-N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-ornithine
CAS Number
268564-10-9
science Other reagents with same CAS 268564-10-9
blur_circular Chemical Specifications
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Molecular Information
Weight
424.49 g/mol
Formula
C₂₃H₂₈N₄O₄
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Registry Numbers
MDL Number
MFCD00672718
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Storage & Handling
Storage
2-8°C, sealed, dry
description Product Description
Used in peptide synthesis to introduce a modified arginine residue with dimethylated guanidine group. The Fmoc group allows for solid-phase synthesis by providing orthogonal protection, while the asymmetrical dimethylation mimics natural post-translational modifications found in proteins. This modification is particularly useful in studying protein arginine methylation, which plays a key role in epigenetic regulation, signal transduction, and RNA processing. The compound helps in preparing methylated histone peptides for use in biochemical assays, enzyme studies, and inhibitor development targeting protein methyltransferases or demethylases. Its structure supports improved cellular uptake and stability in certain peptide-based drug designs.