Inophyllum E is a natural coumarin derivative isolated from Calophyllum inophyllum, used in biochemical research for its potent antiviral properties, particularly against HIV-1. It acts as an inhibitor of HIV integrase, blocking viral replication and integration into host DNA, positioning it as a promising lead compound for novel antiretroviral drug development. Additionally, it exhibits anti-inflammatory effects and anticancer potential, including induction of apoptosis in select cancer cell lines. Due to its natural origin and bioactive profile, it is also explored for dermatological applications, such as in anti-inflammatory skincare formulations.