Liquiritigenin is employed in pharmaceutical and health product industries for its anti-inflammatory properties, aiding in the development of treatments for chronic conditions such as arthritis. Its antioxidant effects help protect cells from oxidative stress, potentially lowering the risk of diseases like heart disease and cancer.

It also exhibits hormone-modulating activity, particularly influencing estrogen levels, and is researched for applications in women's health issues, including menopausal symptoms. Studies suggest it supports nervous system function, may prevent cognitive decline like dementia, and helps alleviate stress.

In cosmetics, liquiritigenin is used in skincare formulations to reduce inflammation, treat acne, and promote skin brightening by inhibiting melanin production, making it ideal for moisturizers and products addressing sun damage or hyperpigmentation.

Additionally, it is incorporated into hair care products to support scalp health by minimizing inflammation and oxidative stress. It features in dietary supplements for potential liver-protective and neuroprotective benefits. It is investigated for functional foods and beverages aimed at metabolic health, influencing glucose metabolism and insulin sensitivity. In research, it serves as a biochemical tool to explore estrogen receptor pathways and cellular anti-aging mechanisms.