Used to treat chronic idiopathic constipation in adults by increasing fluid secretion in the intestines, which helps soften stool and promotes regular bowel movements. Also prescribed for irritable bowel syndrome with constipation (IBS-C) in women aged 18 and older. Works locally in the gut to activate chloride channels, enhancing intestinal motility without significant systemic absorption. Commonly used when other laxatives or fiber supplements are ineffective.