Licochalcone C is primarily studied for its biological activities, particularly in the field of dermatology and skincare. It exhibits strong anti-inflammatory properties, making it useful in formulations targeting skin irritation and redness. The compound also shows antioxidant effects, helping to protect skin cells from oxidative stress caused by environmental factors like UV radiation and pollution.

It has been investigated for its potential in treating acne due to its antimicrobial activity against Propionibacterium acnes, a key bacterium involved in acne development. Additionally, Licochalcone C may help in managing hyperpigmentation by inhibiting melanin production, suggesting a role in skin-brightening or depigmenting products.

Research also points to anticancer potential, where it demonstrates the ability to induce apoptosis and suppress proliferation in certain cancer cell lines, though these applications remain in the preclinical stage. Its multifunctional activity profile makes it a promising candidate for cosmetic, pharmaceutical, and therapeutic development.