Licoricidin is a natural compound primarily studied for its antimicrobial, anticancer, anti-inflammatory, neuroprotective, and antioxidant properties. It demonstrates strong activity against various bacteria, including Gram-positive and Gram-negative strains, drug-resistant ones like methicillin-resistant Staphylococcus aureus (MRSA), and some fungi, making it a potential candidate for new antibiotics. In cancer research, licoricidin inhibits the growth of several cancer cell lines, including lung, prostate, colon, breast, and liver cancers, by inducing cell cycle arrest, promoting apoptosis, and suppressing cell division. It also exhibits anti-inflammatory effects, contributing to therapeutic potential in chronic inflammatory diseases such as arthritis and skin conditions. Additionally, licoricidin has been investigated for neuroprotective properties, suggesting applications in neurodegenerative disorders like Alzheimer’s disease. Its antioxidant capabilities further support uses in skincare products to reduce inflammation, combat free radicals, delay aging, and protect skin from pollution and UV radiation. Due to its natural origin and multitarget biological activities, licoricidin is a promising compound for pharmaceutical and cosmetic development.