Ligustilide is widely used in traditional medicine and modern pharmaceutical research due to its diverse biological activities. It is primarily applied for its anti-inflammatory and neuroprotective effects, making it a candidate in the development of treatments for neurological disorders such as stroke and Alzheimer’s disease. It also exhibits analgesic and antispasmodic properties, commonly utilized in formulations for menstrual pain and gastrointestinal discomfort.

In cardiovascular health, ligustilide helps in improving blood circulation by inhibiting platelet aggregation and dilating blood vessels. It is investigated for its potential in preventing ischemic heart conditions. Additionally, it shows promise in cancer research due to its ability to induce apoptosis in certain tumor cells.

In the cosmetic and skincare industry, ligustilide is valued for its antioxidant properties, helping to reduce oxidative stress and delay skin aging. Its presence in herbal extracts makes it a key component in natural and integrative therapies, especially in East Asian medicine systems.