Used to treat chronic idiopathic constipation in adults by increasing fluid secretion in the intestines, which helps soften stool and promotes regular bowel movements. Also prescribed for irritable bowel syndrome with constipation (IBS-C) in women aged 18 and older, and for opioid-induced constipation in patients with chronic non-cancer pain. Works by activating chloride channels in the intestinal lining, enhancing intestinal transit without relying on stimulant mechanisms.