Manzamine A is a marine-derived alkaloid exhibiting significant antimalarial activity, with potent inhibition against Plasmodium falciparum, including drug-resistant strains. It is being studied as a lead compound for new antimalarial drugs. Additionally, it shows antitumor properties against various cancer cell lines, such as lung, colorectal, and pancreatic cancers, by inducing apoptosis and inhibiting cell proliferation and survival signaling pathways. Research also indicates antiviral effects, including against HIV, as well as neuroprotective properties, suggesting applications in neurodegenerative conditions like Alzheimer’s disease. Its complex structure has inspired synthetic and medicinal chemistry efforts to develop analogs with improved efficacy and safety. However, it remains in the research stage, requiring further studies to evaluate safety and efficacy in humans.