Used in bioconjugation and drug delivery systems, this compound enables site-specific modification of proteins and peptides through its maleimide (MAL) group, which reacts selectively with thiol groups. The PEG11 spacer enhances solubility, reduces aggregation, and prolongs circulation time in vivo by minimizing immune recognition. The lipoamide end promotes cellular uptake and mitochondrial targeting due to its affinity for lipoic acid transporters. Commonly applied in the development of targeted therapeutics, especially in cancer and neurodegenerative disease research, where efficient intracellular delivery and stability are critical.