Used in targeted protein degradation research, particularly in the development of PROTACs (proteolysis-targeting chimeras). The molecule enables the conjugation of a target protein binder to an E3 ubiquitin ligase recruiter through its VCP-NB end, while the Mal-PEG2 portion provides a maleimide group for thiol-specific bioconjugation and a short polyethylene glycol spacer to improve solubility and flexibility. This compound is valuable in creating bifunctional molecules that induce ubiquitination and subsequent degradation of disease-related proteins, especially in oncology and drug discovery. Its design supports efficient linker assembly in bioconjugation strategies for chemical biology and therapeutic development.