Used primarily as a highly reactive sulfonyl fluoride reagent in chemical synthesis, particularly in SuFEx (Sulfur(VI) Fluoride Exchange) click chemistry. It serves as a key building block for modifying biomolecules, enabling the development of covalent inhibitors in drug discovery. Its stability under physiological conditions and selective reactivity with nucleophilic residues like tyrosine make it valuable for protein labeling, bioconjugation, and activity-based protein profiling. Additionally, it is employed in the preparation of functional materials and polymers where robust sulfur-fluoride linkages are required.