2-Chloro-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)acetamide
95%
science Other reagents with same CAS 1957235-51-6
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description Product Description
Used primarily in the synthesis of immunomodulatory and anticancer agents. It serves as a key intermediate in the preparation of targeted protein degraders, particularly cereblon E3 ligase modulators. These compounds are designed to selectively bind and degrade disease-causing proteins, making them valuable in the development of treatments for hematological cancers such as multiple myeloma and myelodysplastic syndromes. Its structure enables conjugation in bifunctional molecules where it links target-binding ligands to E3 ligase recruiters, facilitating ubiquitination and subsequent degradation of specific proteins. Also explored in research settings for optimizing pharmacokinetic properties and selectivity in novel therapeutics.
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