N-((1R, 4R)-4-(3-Chloro-4-cyanophenoxy)cyclohexyl)-6-(4-((4-(2-(2, 6-dioxopiperidin-3-yl)-6-fluoro-1, 3-dioxo-2, 3-dihydro-1H-isoindol-5-yl)piperazin-1-yl)methyl)piperidin-1-yl)pyridazine-3-carboxamide
10mM in DMSO
Reagent
Code: #216277
CAS Number
2222112-77-6
science Other reagents with same CAS 2222112-77-6
blur_circular Chemical Specifications
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Molecular Information
Weight
812.29 g/mol
Formula
C₄₁H₄₃ClFN₉O₆
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Storage & Handling
Storage
-20°C
description Product Description
Used in pharmaceutical research as a targeted protein degrader, specifically functioning as a heterobifunctional PROTAC (proteolysis-targeting chimera). It is designed to selectively recruit specific disease-related proteins to an E3 ubiquitin ligase, inducing ubiquitination and subsequent degradation by the cell's proteasome system. This compound shows potential in oncology research due to its ability to modulate hard-to-target proteins involved in cancer progression. Its structure enables enhanced cell permeability and target specificity, making it valuable in developing therapies for resistant or undruggable targets.
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