Nootkatone is widely used in the fragrance and flavor industry due to its pleasant grapefruit-like aroma. It serves as a natural flavoring agent in foods, beverages, and chewing gums, enhancing citrus notes in products. In perfumery, it is valued for adding fresh, fruity top notes to colognes, soaps, and cosmetic products. Beyond flavor and fragrance, nootkatone has gained attention as a natural insect repellent and pesticide. It is effective against ticks, mosquitoes, and other biting insects, and has been approved by the U.S. Environmental Protection Agency (EPA) for use in insect control products. Its natural origin and low toxicity to mammals make it a favorable alternative to synthetic repellents. Additionally, nootkatone is being studied for potential bioactive properties, including anti-inflammatory and metabolic effects, which may lead to applications in dietary supplements or functional foods.