N-Cbz-piperidine-4-carbonyl Chloride
≥95%
Reagent
Code: #220443
CAS Number
10314-99-5
science Other reagents with same CAS 10314-99-5
blur_circular Chemical Specifications
scatter_plot
Molecular Information
Weight
281.73 g/mol
Formula
C₁₄H₁₆ClNO₃
badge
Registry Numbers
MDL Number
MFCD02677707
inventory_2
Storage & Handling
Storage
2-8°C, avoiding light
description Product Description
Used as an intermediate in the synthesis of pharmaceuticals, particularly in the development of active pharmaceutical ingredients (APIs) where protection of the piperidine nitrogen is required. The Cbz group allows for selective reactivity at the carbonyl chloride site, enabling peptide coupling or amide bond formation under controlled conditions. Commonly applied in medicinal chemistry for constructing complex molecules, including protease inhibitors and receptor agonists/antagonists. Its reactivity makes it suitable for use in both solution-phase and solid-phase synthesis. Handling requires care due to moisture sensitivity and potential for side reactions with protic functional groups.