3-(1-oxo-5-(piperazin-1-yl)isoindolin-2-yl)piperidine-2,6-dione hydrochloride
95%
Reagent
Code: #221047
CAS Number
2222120-31-0
science Other reagents with same CAS 2222120-31-0
blur_circular Chemical Specifications
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Molecular Information
Weight
364.8266 g/mol
Formula
C₁₇H₂₁ClN₄O₃
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Registry Numbers
MDL Number
MFCD32705051
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Storage & Handling
Storage
2-8°C
description Product Description
Used in pharmaceutical research as a key intermediate in the synthesis of targeted protein degraders, particularly cereblon E3 ligase modulators. Its structure enables selective binding to cereblon, making it valuable in developing PROTACs (proteolysis-targeting chimeras) for cancer therapy and immune modulation. The compound's piperazine and piperidine dione moieties enhance solubility and binding affinity, supporting optimization of drug candidates with improved pharmacokinetic profiles.
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