ONO-4059 (GS-4059) hydrochloride

10mM in DMSO

Reagent Code: #221268
fingerprint
CAS Number 1439901-97-9

science Other reagents with same CAS 1439901-97-9

blur_circular Chemical Specifications

scatter_plot Molecular Information
Weight 490.94 g/mol
Formula C₂₅H₂₂N₆O₃·HCl
inventory_2 Storage & Handling
Storage -20°C

description Product Description

Used in the treatment of B-cell malignancies such as chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma (NHL). It functions as a selective inhibitor of Bruton's tyrosine kinase (BTK), a key enzyme in the B-cell receptor signaling pathway. By blocking BTK, it disrupts signals that promote malignant B-cell proliferation and survival, leading to reduced tumor growth. Currently investigated in clinical trials either as monotherapy or in combination with other agents like rituximab or chemotherapy regimens. Shows potential for patients who are refractory to other treatments due to its targeted mechanism and favorable pharmacokinetic profile.

Available Sizes & Pricing

Size Availability Unit Price Quantity
1ml
10-20 days ฿6,590.00
ONO-4059 (GS-4059) hydrochloride
No image available
Used in the treatment of B-cell malignancies such as chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma (NHL). It functions as a selective inhibitor of Bruton's tyrosine kinase (BTK), a key enzyme in the B-cell receptor signaling pathway. By blocking BTK, it disrupts signals that promote malignant B-cell proliferation and survival, leading to reduced tumor growth. Currently investigated in clinical trials either as monotherapy or in combination with other agents like rituximab or chemotherapy regimens. Shows potential for patients who are refractory to other treatments due to its targeted mechanism and favorable pharmacokinetic profile.
Mechanism -
Appearance -
Longevity -
Strength -
Storage -
Shelf Life -
Allergen(s) -
Dosage (Range) -
Dosage (Per Day) -
Mix Method -
Heat Resistance -
Stable in pH range -
Solubility -
Product Types -
INCI -

Purchase History for

Loading purchase history...