Used in antibody-drug conjugates (ADCs) as a linker-payload system, enabling targeted delivery of the potent cytotoxic agent DM1 to cancer cells. The vc-PABC component acts as a cleavable linker that releases DM1 inside the cell after internalization, enhancing therapeutic specificity and reducing systemic toxicity. This construct is particularly effective in tumor-selective drug activation, making it valuable in the development of precision oncology treatments.