PS 48 is widely used as a selective activator of AMP-activated protein kinase (AMPK), making it a valuable tool in metabolic research. It is commonly applied in studies related to cellular energy homeostasis, insulin sensitivity, and glucose uptake. Due to its ability to enhance AMPK activity without affecting upstream kinases, PS 48 is used to investigate pathways involved in diabetes, obesity, and metabolic syndrome. It also shows potential in cancer research, where modulation of metabolic pathways in tumor cells is required. Its cell permeability and specificity support its use in both in vitro and in vivo experimental models.