PD406976
10mM in DMSO
Reagent
Code: #224104
CAS Number
136194-77-9
science Other reagents with same CAS 136194-77-9
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Molecular Information
Weight
377.42 g/mol
Formula
C₂₄H₁₈N₄O
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Registry Numbers
MDL Number
MFCD00236434
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Storage & Handling
Storage
-20°C
description Product Description
Used in research as a selective inhibitor of protein kinase C (PKC) isoforms, particularly PKCβ. It is employed in cellular signaling studies to investigate the role of PKC in processes such as cell proliferation, differentiation, and apoptosis. Commonly applied in cancer research to assess the impact of PKC inhibition on tumor growth and survival pathways. Also utilized in studies related to diabetic complications, where PKCβ activation is implicated in vascular and retinal dysfunction. Its selectivity makes it a valuable tool for dissecting specific PKC-mediated signaling events without broad off-target effects on other kinase families.
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