Palmatine is widely used in traditional medicine due to its significant biological activities. It exhibits strong anti-inflammatory and antioxidant properties, making it useful in managing chronic inflammatory conditions. The compound has demonstrated antimicrobial effects against various bacteria and fungi, supporting its use in treating infections.

It is also studied for its potential neuroprotective benefits, showing promise in improving cognitive function and protecting against neurodegenerative diseases like Alzheimer’s. Palmatine may help regulate blood sugar levels, offering a possible application in diabetes management.

Additionally, it has been explored for its anticancer activity, where it can induce apoptosis and inhibit the growth of certain tumor cells. Due to its ability to cross the blood-brain barrier, palmatine is considered a candidate for developing central nervous system-targeted therapies. Its role in liver protection and cardiovascular health further expands its therapeutic potential.