Pterisolic acid A exhibits significant anti-inflammatory activity by inhibiting the production of nitric oxide (NO) in lipopolysaccharide (LPS)-stimulated microglial cells, suggesting potential use in managing neuroinflammatory conditions. It also demonstrates moderate cytotoxic effects against certain human cancer cell lines, indicating possible applications in anticancer research. Additionally, its presence in fern species known for traditional medicinal use supports its role in natural product-based drug discovery, particularly for developing agents with neuroprotective and antiproliferative properties.