Used in bioconjugation to link biomolecules such as peptides, proteins, or antibodies through thiol-reactive chemistry. The multiple arms allow for high loading capacity and increased stability in biological environments. Commonly applied in drug delivery systems to enhance solubility and circulation time of therapeutic agents. Frequently used in hydrogel formation for tissue engineering due to its ability to form crosslinked networks under mild conditions. Supports surface modification of nanoparticles and medical devices to reduce nonspecific binding and improve biocompatibility. Enables controlled release formulations by tuning crosslinking density. Ideal for creating multifunctional scaffolds in regenerative medicine.