(R)-2-(piperidin-3-yl)isoindoline-1,3-dione
98%
science Other reagents with same CAS 886588-61-0
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description Product Description
Used as a key intermediate in the synthesis of pharmaceutical agents, particularly in the development of targeted protein degraders such as PROTACs (proteolysis-targeting chimeras). Its structural features allow for effective linker attachment between an E3 ligase ligand and a target protein binder. Commonly employed in oncology research due to its ability to engage cereblon (CRBN), an E3 ubiquitin ligase, facilitating the degradation of disease-causing proteins. Also utilized in the design of small molecule therapeutics for immunomodulatory and anti-inflammatory applications. Its chiral piperidine core supports high selectivity and binding affinity in complex biological systems.
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