rel-(3aR,5s,6aS)-N-(3-Methoxy-1,2,4-thiadiazol-5-yl)-5-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)hexahydrocyclopenta[c]pyrrole-2(1H)-carboxamide
98%
science Other reagents with same CAS 1445987-21-2
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description Product Description
This compound is a highly selective inhibitor of JAK1 (Janus kinase 1), used in the treatment of autoimmune and inflammatory disorders such as rheumatoid arthritis, psoriasis, and certain blood disorders associated with aberrant immune responses. Its mechanism of action involves disrupting cytokine signaling pathways that rely on the JAK-STAT pathway, which effectively reduces inflammation and modulates immune responses.
Due to its high specificity for JAK1, it minimizes potential side effects on JAK2, JAK3, or TYK2, providing greater safety in treatment compared to earlier generations of JAK inhibitors. It is formulated as an oral tablet taken once daily, making it convenient for patients requiring long-term therapy.
Additionally, it is under further investigation for other conditions related to chronic inflammation, such as immune-mediated interstitial lung disease and neurological disorders involving inflammation.
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