(2r,4s)-1-[(tert-butoxy)carbonyl]-4-([(9h-fluoren-9-yl)methoxy]carbonylamino)pyrrolidine-2-carboxylicacid

98%

Reagent Code: #231998
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CAS Number 1018332-23-4

science Other reagents with same CAS 1018332-23-4

blur_circular Chemical Specifications

scatter_plot Molecular Information
Weight 452.50 g/mol
Formula C₂₅H₂₈N₂O₆
badge Registry Numbers
MDL Number MFCD11519438
inventory_2 Storage & Handling
Storage Room temperature

description Product Description

This compound is a dual-protected derivative of (2R,4S)-4-aminoproline, featuring a Boc group on the pyrrolidine nitrogen (alpha-amino equivalent) and an Fmoc group on the 4-amino side chain, with the carboxylic acid free for coupling. Widely used in solid-phase peptide synthesis (SPPS), it enables selective incorporation of the modified proline residue into complex peptides. The Fmoc group on the side chain allows for mild base-induced deprotection (typically with piperidine), while the Boc group on the ring nitrogen can be removed under acidic conditions, providing orthogonal protection strategies. Its specific stereochemistry aids in controlling peptide conformation, making it valuable for pharmaceutical research, development of bioactive peptides, peptidomimetics, and drug candidates requiring precise amino acid sequencing and side-chain functionality.

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Size Availability Unit Price Quantity
inventory 100mg
10-20 days ฿7,920.00
(2r,4s)-1-[(tert-butoxy)carbonyl]-4-([(9h-fluoren-9-yl)methoxy]carbonylamino)pyrrolidine-2-carboxylicacid
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This compound is a dual-protected derivative of (2R,4S)-4-aminoproline, featuring a Boc group on the pyrrolidine nitrogen (alpha-amino equivalent) and an Fmoc group on the 4-amino side chain, with the carboxylic acid free for coupling. Widely used in solid-phase peptide synthesis (SPPS), it enables selective incorporation of the modified proline residue into complex peptides. The Fmoc group on the side chain allows for mild base-induced deprotection (typically with piperidine), while the Boc group on the

This compound is a dual-protected derivative of (2R,4S)-4-aminoproline, featuring a Boc group on the pyrrolidine nitrogen (alpha-amino equivalent) and an Fmoc group on the 4-amino side chain, with the carboxylic acid free for coupling. Widely used in solid-phase peptide synthesis (SPPS), it enables selective incorporation of the modified proline residue into complex peptides. The Fmoc group on the side chain allows for mild base-induced deprotection (typically with piperidine), while the Boc group on the ring nitrogen can be removed under acidic conditions, providing orthogonal protection strategies. Its specific stereochemistry aids in controlling peptide conformation, making it valuable for pharmaceutical research, development of bioactive peptides, peptidomimetics, and drug candidates requiring precise amino acid sequencing and side-chain functionality.

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