(2r,4s)-1-[(tert-butoxy)carbonyl]-4-([(9h-fluoren-9-yl)methoxy]carbonylamino)pyrrolidine-2-carboxylicacid
98%
science Other reagents with same CAS 1018332-23-4
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description Product Description
This compound is a dual-protected derivative of (2R,4S)-4-aminoproline, featuring a Boc group on the pyrrolidine nitrogen (alpha-amino equivalent) and an Fmoc group on the 4-amino side chain, with the carboxylic acid free for coupling. Widely used in solid-phase peptide synthesis (SPPS), it enables selective incorporation of the modified proline residue into complex peptides. The Fmoc group on the side chain allows for mild base-induced deprotection (typically with piperidine), while the Boc group on the ring nitrogen can be removed under acidic conditions, providing orthogonal protection strategies. Its specific stereochemistry aids in controlling peptide conformation, making it valuable for pharmaceutical research, development of bioactive peptides, peptidomimetics, and drug candidates requiring precise amino acid sequencing and side-chain functionality.
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