Roxatidine is primarily used as a histamine H2-receptor antagonist, designed to reduce gastric acid secretion in the stomach. It is commonly employed in the management of peptic ulcer disease, including both gastric and duodenal ulcers. By inhibiting acid production, roxatidine helps relieve symptoms such as heartburn and indigestion, and promotes ulcer healing.

It is also used in the treatment of gastroesophageal reflux disease (GERD), where excessive stomach acid flows back into the esophagus, causing irritation and discomfort. Due to its action on acid suppression, roxatidine can provide symptomatic relief and prevent complications associated with chronic acid exposure.

Compared to some other H2 blockers, roxatidine has a relatively long duration of action, allowing for once-daily dosing in certain formulations, which improves patient compliance. It is generally well-tolerated and has been used as an alternative to other acid-suppressing medications, especially in regions where it is available over the counter or by prescription for short-term relief of acid-related conditions.